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• 00:47 1 ago 2026 LauriDenby discusión contribs. creó la página Methotrexate: A Comprehensive Overview Of A Multifaceted Antimetabolite (Página creada con «<br>Methotrexate (MTX) is a cornerstone drug in both oncology and rheumatology, first developed in the 1940s as a folate analogue and antimetabolite. Its ability to inhibit dihydrofolate reductase (DHFR) disrupts nucleotide synthesis, leading to potent antiproliferative, immunosuppressive, and [https://lerablog.org/?s=anti-inflammatory%20effects anti-inflammatory effects]. Over decades, methotrexate has become a first-line agent for rheumatoid arthritis (RA), psoriasi…»)